Antioxidant response versus selenium accumulation in the liver and kidney of the Siberian sturgeon (Acipenser baeri).
Identifieur interne : 000306 ( Main/Exploration ); précédent : 000305; suivant : 000307Antioxidant response versus selenium accumulation in the liver and kidney of the Siberian sturgeon (Acipenser baeri).
Auteurs : Nicole Pacini [Italie] ; Antonia Concetta Elia ; Maria Cesarina Abete ; Ambrosius Josef Martin Dörr ; Paola Brizio ; Laura Gasco ; Marzia Righetti ; Marino PrearoSource :
- Chemosphere [ 1879-1298 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Fishes (physiology), Glutathione (metabolism), Glutathione Reductase (metabolism), Glutathione Transferase (metabolism), Kidney (drug effects), Kidney (metabolism), Lipid Peroxidation (drug effects), Liver (drug effects), Liver (metabolism), Malondialdehyde (metabolism), Reactive Oxygen Species (metabolism), Selenium (metabolism), Selenium (toxicity), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , metabolism : Glutathione, Glutathione Reductase, Glutathione Transferase, Malondialdehyde, Reactive Oxygen Species, Selenium, Water Pollutants, Chemical.
- drug effects : Kidney, Lipid Peroxidation, Liver.
- metabolism : Kidney, Liver.
- physiology : Fishes.
- chemical , toxicity : Selenium, Water Pollutants, Chemical.
- Animals.
Abstract
The aim of this study was to examine the effects of selenium on concentrations of metabolites and enzyme activities acting as antioxidant markers in liver and kidney of Siberian sturgeon Acipenser baeri. Sturgeons were fed selenium cysteine for 30 and 60 d at 1.25, 5, 20mg Sekg(-1). Selenium level in the control feed was 0.32 mg kg(-1). Se concentration was measured in liver, kidney and muscle of every specimen. Sturgeon accumulated Se in tissues with a clear dose-response relationship and the highest Se concentration was recorded in liver. This outcome is lined up with the findings obtained on the antioxidant markers evaluated in both tissues, and in which a dose-response for several biomarkers was recorded in liver. The superoxide dismutase activity in Se-treated fish was generally induced, while catalase activity was lower in liver or unaltered in kidney. The concentrations of glutathione S-transferase, glutathione reductase and total glutathione responded differently for both tissues and were induced in a different way at both endpoints. No changes of glyoxalase I activity were noted for both Se-treated tissues, while for glyoxalase II enzyme in liver a dose-related pattern was found showing a reversible effect (decreased and increased counteractive response) only in the 5 mg kg(-1) group. Moreover, the highest Se concentrations did not cause marked changes in malondialdehyde levels of liver and kidney. The enhancement of glutathione peroxidase activity in Se-treated sturgeon might have prevented the lipid peroxidation in both tissues, providing to the Siberian sturgeon a great defense ability versus the prooxidant effect of selenium.
DOI: 10.1016/j.chemosphere.2013.08.042
PubMed: 24034889
Affiliations:
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last="Abete">Maria Cesarina Abete</name></author><author><name sortKey="Dorr, Ambrosius Josef Martin" sort="Dorr, Ambrosius Josef Martin" uniqKey="Dorr A" first="Ambrosius Josef Martin" last="Dörr">Ambrosius Josef Martin Dörr</name></author><author><name sortKey="Brizio, Paola" sort="Brizio, Paola" uniqKey="Brizio P" first="Paola" last="Brizio">Paola Brizio</name></author><author><name sortKey="Gasco, Laura" sort="Gasco, Laura" uniqKey="Gasco L" first="Laura" last="Gasco">Laura Gasco</name></author><author><name sortKey="Righetti, Marzia" sort="Righetti, Marzia" uniqKey="Righetti M" first="Marzia" last="Righetti">Marzia Righetti</name></author><author><name sortKey="Prearo, Marino" sort="Prearo, Marino" uniqKey="Prearo M" first="Marino" last="Prearo">Marino Prearo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24034889</idno><idno type="pmid">24034889</idno><idno 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baeri).</title><author><name sortKey="Pacini, Nicole" sort="Pacini, Nicole" uniqKey="Pacini N" first="Nicole" last="Pacini">Nicole Pacini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia</wicri:regionArea><wicri:noRegion>06123 Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Elia, Antonia Concetta" sort="Elia, Antonia Concetta" uniqKey="Elia A" first="Antonia Concetta" last="Elia">Antonia Concetta Elia</name></author><author><name sortKey="Abete, Maria Cesarina" sort="Abete, Maria Cesarina" uniqKey="Abete M" first="Maria Cesarina" last="Abete">Maria Cesarina Abete</name></author><author><name sortKey="Dorr, Ambrosius Josef Martin" sort="Dorr, Ambrosius Josef Martin" uniqKey="Dorr A" first="Ambrosius Josef Martin" last="Dörr">Ambrosius Josef Martin Dörr</name></author><author><name sortKey="Brizio, Paola" sort="Brizio, Paola" uniqKey="Brizio P" first="Paola" last="Brizio">Paola Brizio</name></author><author><name sortKey="Gasco, Laura" sort="Gasco, Laura" uniqKey="Gasco L" first="Laura" last="Gasco">Laura Gasco</name></author><author><name sortKey="Righetti, Marzia" sort="Righetti, Marzia" uniqKey="Righetti M" first="Marzia" last="Righetti">Marzia Righetti</name></author><author><name sortKey="Prearo, Marino" sort="Prearo, Marino" uniqKey="Prearo M" first="Marino" last="Prearo">Marino Prearo</name></author></analytic><series><title level="j">Chemosphere</title><idno type="eISSN">1879-1298</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Fishes (physiology)</term><term>Glutathione (metabolism)</term><term>Glutathione Reductase (metabolism)</term><term>Glutathione Transferase (metabolism)</term><term>Kidney (drug effects)</term><term>Kidney (metabolism)</term><term>Lipid Peroxidation (drug effects)</term><term>Liver (drug effects)</term><term>Liver (metabolism)</term><term>Malondialdehyde (metabolism)</term><term>Reactive Oxygen Species (metabolism)</term><term>Selenium (metabolism)</term><term>Selenium (toxicity)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term><term>Glutathione Reductase</term><term>Glutathione Transferase</term><term>Malondialdehyde</term><term>Reactive Oxygen Species</term><term>Selenium</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney</term><term>Lipid Peroxidation</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Kidney</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fishes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Selenium</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to examine the effects of selenium on concentrations of metabolites and enzyme activities acting as antioxidant markers in liver and kidney of Siberian sturgeon Acipenser baeri. Sturgeons were fed selenium cysteine for 30 and 60 d at 1.25, 5, 20mg Sekg(-1). Selenium level in the control feed was 0.32 mg kg(-1). Se concentration was measured in liver, kidney and muscle of every specimen. Sturgeon accumulated Se in tissues with a clear dose-response relationship and the highest Se concentration was recorded in liver. This outcome is lined up with the findings obtained on the antioxidant markers evaluated in both tissues, and in which a dose-response for several biomarkers was recorded in liver. The superoxide dismutase activity in Se-treated fish was generally induced, while catalase activity was lower in liver or unaltered in kidney. The concentrations of glutathione S-transferase, glutathione reductase and total glutathione responded differently for both tissues and were induced in a different way at both endpoints. No changes of glyoxalase I activity were noted for both Se-treated tissues, while for glyoxalase II enzyme in liver a dose-related pattern was found showing a reversible effect (decreased and increased counteractive response) only in the 5 mg kg(-1) group. Moreover, the highest Se concentrations did not cause marked changes in malondialdehyde levels of liver and kidney. The enhancement of glutathione peroxidase activity in Se-treated sturgeon might have prevented the lipid peroxidation in both tissues, providing to the Siberian sturgeon a great defense ability versus the prooxidant effect of selenium.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Abete, Maria Cesarina" sort="Abete, Maria Cesarina" uniqKey="Abete M" first="Maria Cesarina" last="Abete">Maria Cesarina Abete</name><name sortKey="Brizio, Paola" sort="Brizio, Paola" uniqKey="Brizio P" first="Paola" last="Brizio">Paola Brizio</name><name sortKey="Dorr, Ambrosius Josef Martin" sort="Dorr, Ambrosius Josef Martin" uniqKey="Dorr A" first="Ambrosius Josef Martin" last="Dörr">Ambrosius Josef Martin Dörr</name><name sortKey="Elia, Antonia Concetta" sort="Elia, Antonia Concetta" uniqKey="Elia A" first="Antonia Concetta" last="Elia">Antonia Concetta Elia</name><name sortKey="Gasco, Laura" sort="Gasco, Laura" uniqKey="Gasco L" first="Laura" last="Gasco">Laura Gasco</name><name sortKey="Prearo, Marino" sort="Prearo, Marino" uniqKey="Prearo M" first="Marino" last="Prearo">Marino Prearo</name><name sortKey="Righetti, Marzia" sort="Righetti, Marzia" uniqKey="Righetti M" first="Marzia" last="Righetti">Marzia Righetti</name></noCountry><country name="Italie"><noRegion><name sortKey="Pacini, Nicole" sort="Pacini, Nicole" uniqKey="Pacini N" first="Nicole" last="Pacini">Nicole Pacini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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